Slug Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Slug |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Slug Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with Slug with Human and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Slug from other sources has not been determined. Slug antibody detects human Slug protein. Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-. More recently, its expression in breast, esophageal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein. Anti-Slug antibodies are ideal for investigators involved in transcription factors, cell cycle proteins and cancer research. |
| Immunogen | Slug Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide from an internal region of human Slug. |
| Other Names | SLUG, SLUGH |
| Gene, Accession # | SNAI2, Gene ID: 6591, NCBI: NP_003059.1, UniProt: O43623 |
| Catalog # | 600-401-H17 |
| Price | $475 |
| Order / More Info | Slug Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
Profile of ROCKLAND IMMUNOCHEMICALS INC.