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Antigenic Specificity | DR4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | DEAE purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-DR4 Antibody is purified by DEAE purification methods. DR4 antibody has no cross reaction to DR5. Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells. |
Immunogen | Anti-DR4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 20 amino acid peptide near the N-terminus of human DR4. |
Other Names | DR4 Antibody, DR4, APO2, CD261, TRAILR1, TRAILR-1, DR4, Tumor necrosis factor receptor superfamily member 10A, Death receptor 4, TRAIL receptor 1 |
Gene, Accession # | TNFRSF10A, Gene ID: 8797, NCBI: AAC51226, UniProt: O00220 |
Catalog # | 200-401-AX5 |
Price | $475 |
Order / More Info | DR4 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |