CaM Kinase II phospho T286 Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | CaM Kinase II phospho T286 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µL |
| Concentration | Titrated value sufficient to run approximately 10 mini blots. |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-CaM Kinase II pT286 Antibody is directed against CaM Kinase II protein phosphorylated at T286. The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. This antibody is specific for phosphorylated CaM Kinase II. Minimal reactivity occurs against non-phosphorylated CaM Kinase II. Reactivity is completely blocked by treatment with lambda-phosphatase. Reactivity against CaM Kinase II occurs from rat sources. However, reactivity is also expected against human, mouse, and Xenopus. CaM Kinase II antibody reacts with Ca2+/Calmodulin-Dependent Protein Kinase II (CaM Kinase II) which is a multi-functional calcium and calmodulin-dependent protein kinase that mediates cellular responses to a wide variety of intercellular signals. CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity, neurotransmitter synthesis and release, gene expression, ion channel function, carbohydrate metabolism, cytoskeletal function, and Ca2+-homeostasis. Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP and learning. Anti-CaM Kinase II antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research. |
| Immunogen | Anti-CaM Kinase II pT286 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Thr286. |
| Other Names | Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, Camk2a protein |
| Gene, Accession # | Camk2A/B, Gene ID: 25400, NCBI: NP_037052.1, UniProt: P11275 |
| Catalog # | 612-401-C71 |
| Price | $475 |
| Order / More Info | CaM Kinase II phospho T286 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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