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Antigenic Specificity | BFAR |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-BFAR Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with BFAR from other sources has not been determined. The bifunctional apoptosis inhibitor (BFAR) is scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors ('extrinsic pathway') as well as mitochondria-dependent apoptosis ('intrinsic pathway'). Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain may contribute to the anti-apoptotic properties of BFAR. In addition, BFAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. BFAR is also thought to be involved in the regulation of neuronal survival. |
Immunogen | Anti-BFAR antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide near the C-terminus of human BFAR. |
Other Names | BFAR Antibody, BAR, RNF47, BAR, Bifunctional apoptosis regulator, RING finger protein 47 |
Gene, Accession # | BFAR, Gene ID: 51283, NCBI: NP_057645, UniProt: Q9NZS9 |
Catalog # | 600-401-Z58 |
Price | $475 |
Order / More Info | BFAR Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |