Collagen Type VI Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | Collagen Type VI |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, bovine |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 500 µg |
| Concentration | 1.01 mg/mL |
| Applications | ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-Collagen Type VI has been prepared by immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other collagens, human serum proteins and non-collagen extracellular matrix proteins to remove any unwanted specificities. Some class-specific anti-collagens may be specific for three-dimensional epitopes which may result in diminished reactivity with denatured collagen or formalin-fixed, paraffin embedded tissues. This antibody reacts with most mammalian Type VI collagens and has negligible cross-reactivity with Type I, II, III, IV or V collagens. Non-specific cross-reaction of anti-collagen antibodies with other human serum proteins or non-collagen extracellular matrix proteins is negligible. Rockland produces highly active antibodies and conjugates to collagens. Collagens are highly conserved throughout evolution and are characterized by an uninterrupted ''Glycine-X-Y'' triplet repeat that is a necessary part of the triple helical structure. For these reasons, it is often extremely difficult to generate antibodies with specificities to collagens. The development of `type' specific antibodies is dependent on NON-DENATURED three-dimensional epitopes. Rockland extensively purifies collagens for immunization from human and bovine placenta and cartilage by limited pepsin digestion and selective salt precipitation. This preparation results in a native conformation of the protein. Antibodies are isolated from rabbit antiserum and are extensively cross-adsorbed by immunoaffinity purification to produce 'type' specific antibodies. Greatly diminished reactivity and selectivity of these antibodies will result if denaturing and reducing conditions are used for SDS-PAGE and immunoblotting. |
| Immunogen | Collagen Type VI from human and bovine placenta |
| Other Names | rabbit anti-Collagen Type VI antibody, Collagen alpha-1 (VI) chain, Collagen VI antibody, Human mRNA for collagen VI alpha 1 C terminal globular domain antibody |
| Gene, Accession # | COL6A1-COL6A3, Gene ID: 1291, NCBI: AAH52575.1, UniProt: P12109 |
| Catalog # | 600-401-108-0.5 |
| Price | $949 |
| Order / More Info | Collagen Type VI Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | PubMed: 17672847 // 24529431 // 27377666 // 27503167 // 28662206 // 29540474 // 30388216 // 32409724 // 33923774 // 35329980 // 35523828 |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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