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Antigenic Specificity | LRRFIP2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-LRRFIP2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Three isoforms of LRRFIP2 are known to exist; this antibody will recognize all three. LRRFIP2 antibody is predicted to not cross-react with other LRRFIP family members. The leucine-rich repeat FLI-I-interacting protein 2 (LRRFIP2), like the related protein LRRFIP1, was identified in a yeast two-hybrid system through binding to the LRR domain of human FLI. It can activate the Wnt signaling pathway in cultured cells and is thought to be a component of the Wnt signaling pathway that modulates Wnt signaling through interactions with Disheveled to increase the cellular levels and transcription activity of beta-catenin. LRRFIP2 has recently been characterized as a positive regulator of the TLR4 signaling pathway for activating NF-kB during the early host response to LPS stimulation through binding to the TLR adaptor protein MyD88, and that this interaction with MyD88 is governed by phosphorylation of specific residues in LRRFIP2. |
Immunogen | Anti-LRRFIP2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide near the C-terminus of human LRRFIP2. |
Other Names | LRRFIP2 Antibody, HUFI-2, Leucine-rich repeat flightless-interacting protein 2, LRR FLII-interacting protein 2 |
Gene, Accession # | LRRFIP2, Gene ID: 9209, NCBI: NP_006300, UniProt: Q9Y608 |
Catalog # | 600-401-CM8 |
Price | $475 |
Order / More Info | LRRFIP2 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |