Edit |   |
---|---|
Antigenic Specificity | JMJD1A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-JMJD1A Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody will not cross-react with JMJD1B or JMJD1C. The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. JMJD1A is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of STAT3, a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells, and decreased JMJD1A expression correlated with the differentiation of cultured mES cells following the removal of the cytokine LIF. These findings suggest that JMJD1A might be a critical signaling molecule underlying the maintenance of pluripotency in embryonic stem cells. At least two isoforms of JMJD1A are known to exist. |
Immunogen | Anti-JMJD1A antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the N-terminus of human JMJD1A. |
Other Names | JMJD1A Antibody, TSGA, JMJD1, JHDM2A, JHMD2A, JMJD1A, KIAA0742, TSGA, Lysine-specific demethylase 3A, JmjC domain-containing histone demethylation protein 2A |
Gene, Accession # | KDM3A, Gene ID: 55818, NCBI: NP_060903, UniProt: Q9Y4C1 |
Catalog # | 600-401-CB3 |
Price | $475 |
Order / More Info | JMJD1A Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |