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Antigenic Specificity | KPNA4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 100 µg |
Concentration | 1 mg/mL |
Applications | ELISA, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-KPNA4 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with KPNA4 from other sources has not been determined. Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. Molecules containing the classical nuclear localization signal (NLS) are transported into the nucleus by alpha/beta heterodimers. KPNA3 has been shown to be important in the TNF-a-induced nuclear import of NF-kB. It is also involved in the stress-mediated nuclear stabilization of p53 and the nuclear import and replication of HIV-1 in both dividing and non-dividing cells. |
Immunogen | Anti-KPNA4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide near the N-terminus of human KPNA4. |
Other Names | KPNA4 Antibody, QIP1, SRP3, IPOA3, QIP1, Importin subunit alpha-3, Importin alpha Q1, Qip1 |
Gene, Accession # | KPNA4, Gene ID: 3840, NCBI: EAW78632, UniProt: O00629 |
Catalog # | 600-401-CG2 |
Price | $475 |
Order / More Info | KPNA4 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |