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Antigenic Specificity | Histone H3 phospho T6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, C. elegans |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 50 µg |
Concentration | 0.67 mg/ml |
Applications | Chip, Immunohistochemistry, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Histone H3 [p Thr6] was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with human Histone H3.2. A BLAST analysis was used to suggest cross-reactivity with Human, mouse, and C. elegans. Predicted to react with many species including rat, chicken, Xenopus, Drosophila, and plant based on 100% sequence homology. Cross-reactivity with Histone H3 from other sources has not been determined. Phosphorylation as a post-translational modification on histone H3 modulates the ability of proteins to recognize and bind to the H3 tail. When additional modifications to H3 are present, in addition to the native T6 phosphorylation, there is an amplified effect. Several authors suggest that the complexity of these combined PTMs on histone tails should be described as a convoluted language, rather than as a strict code. Since the H3T6 phosphorylation seems to be constitutively present, its de-phosphorylation could be highly significant and affect transcription, repair and replication. Anti-Histone H3 are ideal for researchers interested in Chromatin Modifiers, Chromatin Research, Histones and Modified Histones, and Epigenetics research. |
Immunogen | Histone H3 [p Thr6] affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide surrounding Threonine 6 of human Histone H3.2. |
Other Names | rabbit anti-Histone H3 pT6 antibody, H3.3AH3F3H3F3B, H3.3B, H3 histone, family 3A, histone H3.3, MGC87783, MGC87782, H3pT6 |
Gene, Accession # | HIST2H3C, Gene ID: 126961, NCBI: NP_001005464, UniProt: Q71DI3 |
Catalog # | 600-401-I63 |
Price | $495 |
Order / More Info | Histone H3 phospho T6 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |