SIVA Antibody from ROCKLAND IMMUNOCHEMICALS INC.
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| Antigenic Specificity | SIVA |
| Clone | polyclonal |
| Host Species | Chicken |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 100 µg |
| Concentration | 1 mg/mL |
| Applications | ELISA, IF Microscopy, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Anti-SIVA Antibody is an IgY fraction that has been affinity purified by immunoaffinity purification. Cross reactivity with SIVA from other sources has not been determined. SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFk-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases. |
| Immunogen | Anti-SIVA antibody was prepared from chicken egg fractions produced by repeated immunizations with a 16 amino acid synthetic peptide near the N-terminus of human SIVA. |
| Other Names | SIVA Antibody, SIVA, CD27BP, Siva-1, Siva-2, SIVA, Apoptosis regulatory protein Siva, CD27-binding protein |
| Gene, Accession # | SIVA1, Gene ID: 10572, NCBI: NP_068355, UniProt: O15304 |
| Catalog # | 200-901-EM3 |
| Price | $475 |
| Order / More Info | SIVA Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
| Product Specific References | n/a |
ROCKLAND IMMUNOCHEMICALS INC.
ROCKLAND IMMUNOCHEMICALS INC.
PO Box 5199
Limerick PA 19468
P: 484-791-3823
P: 800.656.7625
F: 484.369.8654
orders@rockland.com
Technical Support: tech@rockland.com
https://www.rockland.com/
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