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Antigenic Specificity | XRCC1 |
Clone | polyclonal |
Host Species | Chicken |
Reactive Species | human, mouse |
Isotype | n/a |
Format | IgY fraction |
Size | 100 µg |
Concentration | 0.93 mg/ml |
Applications | ELISA, IF Microscopy, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This purified antibody is directed against human XRCC1. This product is an IgY fraction antibody purified from monospecific chicken egg yolks by a multi-step process which includes selective precipitation and salt fractionation followed by extensive dialysis against the buffer stated above. XRCC1 (X-Ray Repair Cross Complementing 1) is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Diseases associated with XRCC1 include Spinocerebellar Ataxia, Autosomal Recessive 26 and Gastric Cardia Carcinoma. Anti-XRCC1 Antibody is useful for researchers interested in Cancer research and DNA repair. |
Immunogen | Anti-XRCC1 antibody was prepared from eggs of chickens laid after repeated immunizations with a synthetic peptide corresponding to a N-Terminal portion of human XRCC1 conjugated to Keyhole Limpet Hemocyanin (KLH). A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to human and 91% to mouse, rat, and Chinese hamster. |
Other Names | Chicken Anti-X-Ray Repair Cross Complementing 1 Antibody, X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 1, X-Ray Repair Cross-Complementing Protein 1, DNA Repair Protein XRCC1, SCAR26, RCC |
Gene, Accession # | XRCC1, Gene ID: 7515, NCBI: NP_006288.2, UniProt: P18887 |
Catalog # | 200-901-MG5 |
Price | $475 |
Order / More Info | XRCC1 Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
Product Specific References | n/a |