Mouse NOTCH1 Protein from BIORBYT LTD.
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| Product Name | Mouse NOTCH1 Protein |
| Description | NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Purity 95.00%. MW: 55.4 kDa |
| Size | 100 ug, 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | NOTCH1,Notch 1,hN1,TAN1 |
| Gene, Accession, CAS # | NCBI: NP_032740.3 |
| Catalog # | orb653659 |
| Price | $587 |
| Order / More Info | Mouse NOTCH1 Protein from BIORBYT LTD. |
| Product Specific References | n/a |
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