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Product Name | HLA-A2 Antibody Kit, anti-human, FITC, REAlease® |
Description | HLA-A2 Antibody Kit, anti-human, FITC, REAlease®. Clone REAL314 is an antibody fragment derived from the full HLA-A2 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity. | Clone REAL314 recognizes the class I human leukocyte antigen A2 (HLA-A2). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and a soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8-10 amino acids long and play an important role in recognition of virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with natural killer (NK) cell receptors to modulate the activity of NK cells. | The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes. |
Size | 100 tests |
Concentration | 1:50 |
Applications | Flow cytometry |
Other Names | MHC class I HLA-A2 |
Gene, Accession, CAS # | n/a |
Catalog # | 130-124-859 |
Price | $385 |
Order / More Info | HLA-A2 Antibody Kit, anti-human, FITC, REAlease® from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Bjorkman, P. J. et al. (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329 (6139): 506-512. | Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110 (2): 163-169. | Smith, S. N. et al. (2013) Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes. J. Mol. Biol. 425 (22): 4496-4507. |