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Product Name | EIF2B1, 1-305aa, Human, His tag, E Coli |
Description | Purity > 90% by SDS-PAGE. EIF2B1 is one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Phosphorylation of eIF2 inhibits GEF activity of EIF2B, an inhibition that requires the eIF2B1 subunit. Defects in eIF2B1 are a cause of leukoencephalopathy with vanishing white matter (VWM), a brain disease that is characterized by head trauma and motor deterioration. Recombinant human EIF2B1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography. MW: 35.8 kDa (325aa) confirmed by MALDI-TOF |
Size | 0.01 mg, 0.05 mg |
Concentration | 0.5 mg/ml (determined by Bradford assay) |
Applications | SDS-PAGE |
Other Names | [Eukaryotic translation initiation factor 2B subunit 1 alpha 26kD; Eukaryotic translation initiation factor 2B; subunit 1 alpha; 26kD; EIF-2B; EIF-2Balpha; EIF2B; EIF2BA; MGC117409; MGC125868; MGC125869], [EIF2B1; EIF2B1; EIF2B; EIF2BA; EIF2BA] |
Gene, Accession, CAS # | [EIF2B1], Gene ID: 1967, NCBI: NP_001405, UniProt: Q14232 |
Catalog # | MBS204083 |
Price | $310, $720 |
Order / More Info | EIF2B1, 1-305aa, Human, His tag, E Coli from MYBIOSOURCE INC. |
Product Specific References | Van der Knaap M.S. et al. (2002) Ann. Neurol 51: 264-270 ; Mohammad-Qureshi S.S. et al. (2007) Mol. Cell. Biol. 27: 5225-5234. |