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Product Name | Recombinant Human Complement factor I (CFI) |
Description | Sequence: 19-583. Full Length of Mature Protein. Purity >85% (SDS-PAGE). This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by ac. MW: 65,750 Da |
Size | 0.05 mg (E. coli), 0.05 mg (Yeast), 0.05 mg (Baculovirus) |
Concentration | n/a |
Applications | n/a |
Other Names | [complement factor I isoform 2 preproprotein; Complement factor I; complement factor I; complement factor I; C3B/C4B inactivator], [CFI; CFI; FI; IF; KAF; AHUS3; ARMD13; C3BINA; C3b-INA; IF] |
Gene, Accession, CAS # | [CFI], Gene ID: 3426, NCBI: NP_000195.2, UniProt: P05156 |
Catalog # | MBS954952 |
Price | $990, $1030, $1270 |
Order / More Info | Recombinant Human Complement factor I (CFI) from MYBIOSOURCE INC. |
Product Specific References | n/a |