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Product Name | CD59, 26-102aa, Human, His tag, E Coli |
Description | Purity > 85% by SDS-PAGE. CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. It also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Recombinant human CD59 protein, fused to His-tag at N-terminus, was expressed i. MW: 11.3 kDa (100aa), confirmed by MALDI-TOF |
Size | 0.02 mg, 0.1 mg |
Concentration | 0.5 mg/ml (determined by Bradford assay) |
Applications | SDS-PAGE |
Other Names | [CD59 glycoprotein; 16.3A5; 1F5; EJ16; EJ30; EL32; G344; HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20], [CD59; CD59; 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20; MIC11; MIN1; MIN2; MIN3; MSK21; HRF-20; HRF20; MAC-IP; MACIF; MIRL] |
Gene, Accession, CAS # | [CD59], Gene ID: 966, NCBI: NP_000602, UniProt: P13987 |
Catalog # | MBS205092 |
Price | $310, $720 |
Order / More Info | CD59, 26-102aa, Human, His tag, E Coli from MYBIOSOURCE INC. |
Product Specific References | Ninomiya H., et al (1992). J. Biol. Chem. 267: 13675-13680 ; Rudd P.M., et al (1997). J. Biol. Chem. 272:7229-7244 |