Edit |   |
---|---|
Product Name | Recombinant Human ICOS Ligand / B7-H2 / ICOSLG Protein (His tag) |
Description | Purity > 98 % as determined by SDS-PAGE. Background: Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both. MW: 20,120 Da |
Size | 0.1 mg, 0.2 mg |
Concentration | n/a |
Applications | n/a |
Other Names | [B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, KIAA0653, LICOS] |
Gene, Accession, CAS # | [ICOSLG], Gene ID: 23308, NCBI: NP_056074.1, UniProt: O75144 |
Catalog # | MBS2545745 |
Price | $435, $635 |
Order / More Info | Recombinant Human ICOS Ligand / B7-H2 / ICOSLG Protein (His tag) from MYBIOSOURCE INC. |
Product Specific References | n/a |