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Product Name | Recombinant human MBD3 protein |
Description | Domain: 1-291aa. Recombinant human MBD3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 35.2 kDa (314aa) confirmed by MALDI-TOF. Purity > 85% by SDS-PAGE. Methyl-CpG-binding domain protein 3, also known as MBD3, is a member of the MBD family of transcriptional repressors. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex |
Size | 10ug, 50ug, 250ug |
Concentration | 0.25mg/ml (determined by Bradford assay) |
Applications | SDS-PAGE |
Other Names | Methyl-CpG-binding domain protein 3, Methyl CpG binding domain protein 3, Methyl-CpG-binding protein MBD3 |
Gene, Accession, CAS # | NCBI: NP_003917, UniProt: O95983 |
Catalog # | ATGP1747 |
Price | $105, $320, $960 |
Order / More Info | Recombinant human MBD3 protein from NKMAX Co. Ltd. |
Product Specific References | n/a |