Description | Domain: 26-132aa. Recombinant human SLPI, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. MW: 14 kDa (128aa) confirmed by MALDI-TOF. Purity > 80% by SDS-PAGE. SLPI is a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity |
Other Names | secretory leukocyte peptidase inhibitor, Antileukoproteinase, ALK1, ALP, BLPI, HuSI, HuSI-I, MPI, WAP4, WFDC4, secretory leukocyte peptidase inhibitor, ALK 1, Antileukoproteinase 1, Antileukoproteinase1, HuSI 1, HuSI I, Protease inhibitor WAP4, Secretory leukocyte protease inhibitor, Seminal proteinase inhibitor, WAP four disulfide core domain protein 4, WAP 4, WFDC 4 |