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Product Name | Recombinant human IL-10 protein |
Description | Domain: 19-178aa. Recombinant human IL-10, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. MW: 19.4 kDa (166aa). Purity > 95% by SDS-PAGE. IL-10, also known as Interleukin-10, is an anti-inflammatory cytokine. It inhibits the synthesis of pro-inflammatory cytokines like IFN-gamma, IL2, IL3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. This protein has effects in immunoregulation and inflammation and down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. This protein controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling |
Size | 10ug, 20ug, 50ug, 100ug, 250ug, 500ug, 1mg |
Concentration | 0.5mg/ml (determined by Bradford assay) |
Applications | SDS-PAGE, Bioactivity |
Other Names | Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF, GVHDS, IL10A, TGIF, T-cell growth inhibitory factor |
Gene, Accession, CAS # | NCBI: NP_000563, UniProt: P22301 |
Catalog # | ATGP3920 |
Price | $160, $280, $460, $770, $1340, $2300, $3840 |
Order / More Info | Recombinant human IL-10 protein from NKMAX Co. Ltd. |
Product Specific References | Lee HM, et al. A comparative study of the effects of inhibitory cytokines on human natural killer cells and the mechanistic features of transforming growth factor-beta. (Cell Immunol. 2014){https://pubmed.ncbi.nlm.nih.gov/24879062/} |