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Product Name | Recombinant human Leptin/OB protein |
Description | Domain: 22-167aa. Recombinant human leptin was overexpressed as insoluble protein aggregate in E. coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. MW: 16 kDa (147aa) confirmed by MALDI-TOF. Purity > 95% by SDS-PAGE. Human leptin is a 16-kDa nonglycosylated hormone that is produced in mature adipocytes. Leptin acts primarily in the hypothalamus to reduce food intake and body weight. In ob/ob mice, the gene encoding leptin is mutated, resulting in morbid obesity and associated abnormalities, including hyperphagia, hypothermia, diabetes and infertility. The function of leptin in regulating appetite and metabolism, as well as the possibility of using leptin as a therapeutic agent, are currently under intense investigation |
Size | 20ug, 100ug, 500ug |
Concentration | 1mg/ml (determined by Bradford assay) |
Applications | SDS-PAGE |
Other Names | LEP, OB, OBS, Leptin, Obesity factor, Obese protein, Leptin, Leptin Murine Obesity Homolog, Leptin Precursor Obesity Factor, Obesity, Obesity homolog mouse, Obesity Murine Homolog Leptin, |
Gene, Accession, CAS # | NCBI: NP_000221, UniProt: P41159 |
Catalog # | LEP3002 |
Price | $55, $170, $505 |
Order / More Info | Recombinant human Leptin/OB protein from NKMAX Co. Ltd. |
Product Specific References | Lee EN, et al. Stabilizing peptide fusion for solving the stability and solubility problems of therapeutic proteins. Pharm Res. 2005 Oct;22(10):1735-46.{https://pubmed.ncbi.nlm.nih.gov/16180132/} |