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Product Name | Recombinant human Selenoprotein R/MSRB1 protein |
Description | Domain: 1-116aa. Recombinant human SEPX1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. MW: 14.8 kDa (136aa) confirmed by MALDI-TOF. Purity > 90% by SDS-PAGE. SEPX1, also known as Methionine sulfoxide reductase B1 (MSRB1), is a selenoprotein. Methionine sulfoxide reductases (MSRs) catalyze reduction of free and protein-bound methionine sulfoxides to corresponding methionines. The oxidation of methionine by ROS generates a diastereomeric mixture of methionine-S-sulfoxide (Met-S-SO) and methionine-R-sulfoxide (Met-R-SO). Two distinct enzyme families evolved for reduction of these sulfoxides, with methionine-S-sulfoxide reductase (MsrA) being stereospecific for Met-S-SO and methionine-R-sulfoxide reductase (MsrB) for Met-R-SO. In bacteria, the selenocystein (Sec/u) element is located immediately following the uGA codon within the reading frame for the selenoprotein so we mutated Sec-95 to Cys |
Size | 10ug, 50ug, 250ug |
Concentration | 0.5mg/ml (determined by Bradford assay) |
Applications | SDS-PAGE |
Other Names | HSPC270, Methionine-R-sulfoxide reductase B1, MsrB1, Selenoprotein X, SELENOR, SELENOX, SelR, SelX, SepR, SEPX1 |
Gene, Accession, CAS # | NCBI: NP_057416, UniProt: Q9NZV6 |
Catalog # | ATGP0735 |
Price | $80, $240, $720 |
Order / More Info | Recombinant human Selenoprotein R/MSRB1 protein from NKMAX Co. Ltd. |
Product Specific References | n/a |