V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog Pseudogene (ERAS) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog Pseudogene (ERAS) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog Pseudogene (ERAS) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein A purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Point mutations of several amino acids of human RAS, including gly12, ala59, or glu63, render the protein constitutively active. Embryonic stem cell-expressed Ras (ERAS) has serine, alanine, and asparagine at the positions corresponding to gly12, ala59, and glu63 of human RAS, suggesting that it is constitutively active.The PI3K (phosphoinositide 3-kinase) pathway is important for proliferation, survival and maintenance of pluripotency in ES cells. The PI3K pathway is activated by growth factors and cytokines including insulin and leukaemia inhibitory factor. In addition to these exogenous factors, the PI3K pathway is endogenously activated by the constitutively active Ras family protein ERas (ES cell-expressed Ras). ERas null ES cells maintained pluripotency but show significantly reduced growth and tumorigenicity, which can be rescued by expression of ERas cDNA or by activated phosphatidylinositol 3-hydroxykinase. The transforming oncogene ERAS appears to be important in the tumor-like growth properties of ES cells. |
| Immunogen | KLH-conjugated synthetic peptide between 51-81 amino acids from the N-terminal region of human ERAS. |
| Other Names | ERAS, HRAS2, HRASP, GTPase ERas, Embryonic stem cell-expressed Ras, E-Ras, ERAS, ERAS, ERAS , ERAS , HRAS2, HRAS2, HRAS2 , HRAS2 , HRASP, HRASP, HRASP , HRASP , GTPase ERas, GTPase ERas, GTPase ERas , GTPase ERas , Embryonic stem cell-expressed Ras, Embryonic stem cell-expressed Ras, Embryonic stem cell-expressed Ras , Embryonic stem cell-expressed Ras , E-Ras, E-Ras, E-Ras , E-Ras |
| Gene, Accession # | UniProt: Q7Z444 |
| Catalog # | abx028240 |
| Price | please inquire |
| Order / More Info | V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog Pseudogene (ERAS) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies