Core-Binding Factor Subunit Beta (CBFB) Antibody from ABBEXA LTD

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Antigenic SpecificityCore-Binding Factor Subunit Beta (CBFB)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse
Isotypen/a
Formataffinity purified
Size20 µl, 50 µl, 100 µl, 200 µl
Concentration> 0.5 mg/ml
ApplicationsWB, IHC, IF/ICC
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionCBFB antibody is a Rabbit polyclonal antibody against CBFB. The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.
ImmunogenRecombinant protein of human CBFB.
Other NamesCBFB, CBF beta, PEBP2B, PEA2 beta, PEBP2 beta, Core-binding factor subunit beta, Polyomavirus enhancer-binding protein 2 beta subunit, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit, core-binding factor, beta subunit, CBF-beta, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 beta subunit, polyomavirus enhancer, CBFB, CBFB, CBFB , CBFB , CBF beta, CBF beta, CBF beta , CBF beta , PEBP2B, PEBP2B, PEBP2B , PEBP2B , PEA2 beta, PEA2 beta, PEA2 beta , PEA2 beta , PEBP2 beta, PEBP2 beta, PEBP2 beta , PEBP2 beta , Core-binding factor subunit beta, Core-binding factor subunit beta, Core-binding factor subunit beta , Core-binding factor subunit beta , Polyomavirus enhancer-binding protein 2 beta subunit, Polyomavirus enhancer-binding protein 2 beta subunit, Polyomavirus enhancer-binding protein 2 beta subunit , Polyomavirus enhancer-binding protein 2 beta subunit , SL3-3 enhancer factor 1 subunit beta, SL3-3 enhancer factor 1 subunit beta, SL3-3 enhancer fac
Gene, Accession #CBFB, Gene ID: 865, UniProt: Q13951
Catalog #abx004055
Priceplease inquire
Order / More InfoCore-Binding Factor Subunit Beta (CBFB) Antibody from ABBEXA LTD
Product Specific Referencesn/a
ABBEXA LTD
ABBEXA LTD
ABBEXA LTD
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Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950

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