Sialic Acid Binding Ig Like Lectin 11 (SIGLEC11) Antibody from ABBEXA LTD
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| Antigenic Specificity | Sialic Acid Binding Ig Like Lectin 11 (SIGLEC11) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIM). SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. Sequence analysis predicted that the 697-amino acid SIGLEC10 protein contains a signal peptide, an N-terminal V-set Ig-like domain and four C2-set Ig-like domains, five potential N-linked glycosylation sites, a transmembrane region, and a 126-residue cytoplasmic tail with 3 putative ITIMs. Northern blot analysis detected a major 3.0-kb SIGLEC10 transcript, with highest levels in spleen, lymph node, blood leukocytes, and appendix. Little or no expression was observed in pancreas, thyroid, and testis. Flow cytometric analysis demonstrated eosinophil-specific expression of SIGLEC10, but at a lower level than that of SIGLEC8. Expression was also detected on monocytes and a CD16-positive/CD56-negative natural killer-like lymphocyte population. After sialidase treatment, which is necessary for unmasking the sialic acid-binding site on SIGLECs interacting with cell surface sialic acids, cells expressing SIGLEC10 bound to red blood cells. Immunoprecipitation analysis indicated expression of a 100 to 120-kD monomeric protein, higher than the predicted molecular mass, suggesting that SIGLEC10 is glycosylated. |
| Immunogen | KLH-conjugated synthetic peptide between 631-662 amino acids from the C-terminal region of human SIGLEC11. |
| Other Names | SIGLEC11, Sialic acid-binding Ig-like lectin 11, SIGLEC11, SIGLEC11, SIGLEC11 , SIGLEC11 , Sialic acid-binding Ig-like lectin 11, Sialic acid-binding Ig-like lectin 11, Sialic acid-binding Ig-like lectin 11 , Sialic acid-binding Ig-like lectin 11 |
| Gene, Accession # | SIGLEC11, UniProt: Q96RL6 |
| Catalog # | abx028723 |
| Price | please inquire |
| Order / More Info | Sialic Acid Binding Ig Like Lectin 11 (SIGLEC11) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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