Serine/threonine-Protein Kinase TAO1 (TAOK1) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Serine/threonine-Protein Kinase TAO1 (TAOK1) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Serine/threonine-Protein Kinase TAO1 (TAOK1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TAOK1 is an upstream activator of Mark. TAOK1 phosphorylated Mark on a threonine within its activation loop. In brain, TAOK1 also phosphorylated a fraction of Mark on a nearby serine, and this phosphorylation inhibited Mark activity. In cells, TAOK1 activity enhanced microtubule dynamics through activation of Mark and led to phosphorylation and detachment of microtubule-associated proteins from microtubules. TAOK1 also activated JNK in vitro. Overexpression of TAOK1 in a human nonsmall cell lung carcinoma cell line induced apoptotic morphologic changes, including cell contraction, membrane blebbing, and apoptotic body formation. Apoptotic stimuli increased the catalytic activity of endogenous TAOK1 and JNK, and dominant-negative JNK or JNK inhibition blocked the apoptotic morphologic responses to TAOK1. TAOK1 also stimulated cleavage and activation of ROCK1 by caspases, leading to cell contraction and membrane blebbing. TAOK1 was itself a substrate for caspase-3. TAOK1 is indeed involved in the execution phase of apoptosis. |
| Immunogen | KLH-conjugated synthetic peptide between 620-650 amino acids from the Central region of human TAOK1. |
| Other Names | TAOK1, KIAA1361, MAP3K16, MARKK, Serine/threonine-protein kinase TAO1, Kinase from chicken homolog B, MARK Kinase, Prostate-derived sterile 20-like kinase 2, Thousand and one amino acid protein kinase 1, Thousand and one amino acid protein 1, STE20-like kinase PSK2, hKFC-B, TAOK1, TAOK1, TAOK1 , TAOK1 , KIAA1361, KIAA1361, KIAA1361 , KIAA1361 , MAP3K16, MAP3K16, MAP3K16 , MAP3K16 , MARKK, MARKK, MARKK , MARKK , Serine/threonine-protein kinase TAO1, Serine/threonine-protein kinase TAO1, Serine/threonine-protein kinase TAO1 , Serine/threonine-protein kinase TAO1 , Kinase from chicken homolog B, Kinase from chicken homolog B, Kinase from chicken homolog B , Kinase from chicken homolog B , MARK Kinase, MARK Kinase, MARK Kinase , MARK Kinase , Prostate-derived sterile 20-like kinase 2, Prostate-derived sterile 20-like kinase 2, Prostate-derived sterile 20-like kinase 2 , Prostate-derived sterile 20-like kinase 2 , Thousand and one amino acid protein kinase 1, Thousand and one amino |
| Gene, Accession # | UniProt: Q7L7X3 |
| Catalog # | abx033166 |
| Price | please inquire |
| Order / More Info | Serine/threonine-Protein Kinase TAO1 (TAOK1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies