TATA Box Binding Protein (TBP) Antibody from ABBEXA LTD
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| Antigenic Specificity | TATA Box Binding Protein (TBP) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. |
| Immunogen | KLH-conjugated synthetic peptide between 210-239 amino acids from the Central region of human TBP. |
| Other Names | TBP, TATA-Box Binding Protein, Transcription Initiation Factor TFIID TBP Subunit, TATA Sequence-Binding Protein, TATA-Box Factor, GTF2D1, TFIID, TATA-Box Binding Protein N-Terminal Domain, TATA-Box-Binding Protein, TATA-Binding Factor, GTF2D, SCA17, HDL4, TF2D, TATA Binding Protein, TATA Box Binding Protein, MGC117320, MGC126054, MGC126055, tbp-, TBP, TBP, TBP , TBP , TATA-Box Binding Protein, TATA-Box Binding Protein, TATA-Box Binding Protein , TATA-Box Binding Protein , Transcription Initiation Factor TFIID TBP Subunit, Transcription Initiation Factor TFIID TBP Subunit, Transcription Initiation Factor TFIID TBP Subunit , Transcription Initiation Factor TFIID TBP Subunit , TATA Sequence-Binding Protein, TATA Sequence-Binding Protein, TATA Sequence-Binding Protein , TATA Sequence-Binding Protein , TATA-Box Factor, TATA-Box Factor, TATA-Box Factor , TATA-Box Factor , GTF2D1, GTF2D1, GTF2D1 , GTF2D1 , TFIID, TFIID, TFIID , TFIID , TATA-Box Binding Protein N-Terminal Domain, TATA- |
| Gene, Accession # | TBP, NCBI: NP_001165556.1, NP_003185.1, UniProt: P20226 |
| Catalog # | abx032930 |
| Price | please inquire |
| Order / More Info | TATA Box Binding Protein (TBP) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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