Antigen Peptide Transporter 1 (TAP1) Antibody from ABBEXA LTD
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| Antigenic Specificity | Antigen Peptide Transporter 1 (TAP1) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding. TAP is also inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP is down-regulated by human Epstein-barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. TAP1 and TAP2 form a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP, inducible by interferon gamma, belongs to the ABC transporter family, MDR subfamily. |
| Immunogen | KLH-conjugated synthetic peptide between 765-794 amino acids from the C-terminal region of human TAP1. |
| Other Names | APT1, ATP-binding cassette sub-family B member 2, Peptide supply factor 1, Peptide transporter PSF1, PSF-1, Peptide transporter TAP1, Peptide transporter involved in antigen processing 1, Really interesting new gene 4 protein, TAP1, ABCB2, PSF1, RING4, Y3, ABC17, TAP1N, D6S114E, TAP1*0102N, Antigen peptide transporter 1, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), FLJ26666, FLJ41500, ABC transporter, MHC 1, ATP-binding cassette transporter, ATP-binding cassette, sub-family B (MDR/TAP), mem, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), APT1, APT1, APT1 , APT1 , ATP-binding cassette sub-family B member 2, ATP-binding cassette sub-family B member 2, ATP-binding cassette sub-family B member 2 , ATP-binding cassette sub-family B member 2 , Peptide supply factor 1, Peptide supply factor 1, Peptide supply factor 1 , Peptide supply factor 1 , Peptide transporter PSF1, Peptide transporter PSF1, Peptide transporter PSF1 , Peptide transporter PSF1 , PSF-1, PS |
| Gene, Accession # | UniProt: Q03518 |
| Catalog # | abx025108 |
| Price | please inquire |
| Order / More Info | Antigen Peptide Transporter 1 (TAP1) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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