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Antigenic Specificity | Cytochrome P450 2D6 (CYP2D6) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB, IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Immunogen | KLH-conjugated synthetic peptide between 76-105 amino acids from the N-terminal region of human CYP2D6. |
Other Names | CYP2D, P450C2D, CPD6, CYP2DL1, P450-DB1, Cytochrome P450 Family 2 Subfamily D Polypeptide 6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450DB1, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 2D6, CYP2D, CYP2D, CYP2D , CYP2D , P450C2D, P450C2D, P450C2D , P450C2D , CPD6, CPD6, CPD6 , CPD6 , CYP2DL1, CYP2DL1, CYP2DL1 , CYP2DL1 , P450-DB1, P450-DB1, P450-DB1 , P450-DB1 , Cytochrome P450 Family 2 Subfamily D Polypeptide 6, Cytochrome P450 Family 2 Subfamily D Polypeptide 6, Cytochrome P450 Family 2 Subfamily D Polypeptide 6 , Cytochrome P450 Family 2 Subfamily D Polypeptide 6 , Cytochrome P450-DB1, Cytochrome P450-DB1, Cytochrome P450-DB1 , Cytochrome P450-DB1 , Debrisoquine 4-hydroxylase, Debrisoquine 4-hydroxylase, Debrisoquine 4-hydroxylase , Debrisoquine 4-hydroxylase , CYP2D6, CYP2D6, CYP2D6 , CYP2D6 , CYP2D7AP, CYP2D7AP, CYP2D7AP , CYP2D7AP , CYP2D7BP, CYP2D7BP, CYP2D7BP , CYP2D7BP , CY |
Gene, Accession # | CYP2D6, Gene ID: 1565, UniProt: P10635 |
Catalog # | abx028111 |
Price | please inquire |
Order / More Info | Cytochrome P450 2D6 (CYP2D6) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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