Beta-Secretase 2 (BACE2C) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Beta-Secretase 2 (BACE2C) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Beta-Secretase 2 (BACE2C) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Amyloid-beta peptide aggregation is a signature of Alzheimer disease and a frequent complication of adult Down syndrome patients. Amyloid-beta is generated by proteolytic processing of the amyloid precursor protein (APP) by beta and gamma-secretase at the N and C termini, respectively. Presenilin-1 is involved in the gamma-secretase activity. BACE is a transmembrane aspartyl protease with beta-secretase activity. BACE2, also termed ALP56 has 2 pepsin-like active centers, a signal sequence, a propeptide, and a long C-terminal extension including a transmembrane domain, with expression in a wide array of tissues. Northern blot analysis revealed low expression of 2.0 and 2.6-kb BACE2 transcripts in most fetal and adult tissues, with higher expression in adult colon, kidney, pancreas, placenta, prostate, stomach, and trachea. Low levels were also detected in brain, with somewhat higher expression in medulla and spinal cord. In situ hybridization analysis of rat brain found low-level BACE2 expression in contrast to BACE expression. The BACE2 expression pattern does not appear to be consistent with that of a beta-secretase. BACE2 has been mapped to 21q22.3, within the Down syndrome critical region. |
| Immunogen | KLH-conjugated synthetic peptide between 310-339 amino acids from the C-terminal region of human BACE2C. |
| Other Names | BACE2, AEPLC, ALP56, ASP21, Beta-secretase 2, Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-site amyloid precursor protein cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, BACE2, BACE2, BACE2 , BACE2 , AEPLC, AEPLC, AEPLC , AEPLC , ALP56, ALP56, ALP56 , ALP56 , ASP21, ASP21, ASP21 , ASP21 , Beta-secretase 2, Beta-secretase 2, Beta-secretase 2 , Beta-secretase 2 , Aspartic-like protease 56 kDa, Aspartic-like protease 56 kDa, Aspartic-like protease 56 kDa , Aspartic-like protease 56 kDa , Aspartyl protease 1, Aspartyl protease 1, Aspartyl protease 1 , Aspartyl protease 1 , Beta-site amyloid precursor protein cleaving enzyme 2, Beta-site amyloid precursor protein cleaving enzyme 2, Beta-site amyloid precursor protein cleaving enzyme 2 , Beta-site amyloid precursor protein cleaving enzyme 2 , Down region aspartic protease, Down region aspartic protease, Down region aspartic protease , Down region asp |
| Gene, Accession # | UniProt: Q9Y5Z0 |
| Catalog # | abx025107 |
| Price | please inquire |
| Order / More Info | Beta-Secretase 2 (BACE2C) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies