G1/S-Specific Cyclin-E1 (CCNE1) Antibody from ABBEXA LTD

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Antigenic SpecificityG1/S-Specific Cyclin-E1 (CCNE1)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatpeptide affinity purified
Size80 µl, 400 µl,
Concentrationn/a
ApplicationsELISA, WB, IHC, FCM
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DescriptionCyclin E1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin E1 forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E1 accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of Cyclin E1 has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.
ImmunogenKLH-conjugated synthetic peptide between 373-402 amino acids from the C-terminal region of human CCNE1.
Other NamesCCNE, Cyclin E1, CCNE1, G1/S-specific cyclin-E1, CCNE, CCNE, CCNE , CCNE , Cyclin E1, Cyclin E1, Cyclin E1 , Cyclin E1 , CCNE1, CCNE1, CCNE1 , CCNE1 , G1/S-specific cyclin-E1, G1/S-specific cyclin-E1, G1/S-specific cyclin-E1 , G1/S-specific cyclin-E1
Gene, Accession #CCNE1, UniProt: P24864
Catalog #abx032766
Priceplease inquire
Order / More InfoG1/S-Specific Cyclin-E1 (CCNE1) Antibody from ABBEXA LTD
Product Specific Referencesn/a
ABBEXA LTD
ABBEXA LTD
ABBEXA LTD
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