c-Jun (pS243) Antibody from ABBEXA LTD
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| Antigenic Specificity | c-Jun (pS243) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | WB, IHC, IF/ICC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | c-Jun (pS243) Antibody is a Rabbit Polyclonal antibody against c-Jun (pS243). c-Jun is a member of the Jun Family containing c-Jun, JunB and JunD, and is a component of the transcription factor AP-1 (activator protein-1). AP-1 is composed of dimers of Fos, Jun and ATF family members and binds to and activates transcription at TRE/AP-1 elements (reviewed in 1). Extracellular signals including growth factors, chemokines and stress activate AP-1-dependent transcription. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK (reviewed in 2). Knock-out studies in mice have shown that c-Jun is essential for embryogenesis (3), and subsequent studies have demonstrated roles for c-Jun in various tissues and developmental processes including axon regeneration (4), liver regeneration (5) and T cell development (6). AP-1 regulated genes exert diverse biological functions including cell proliferation, differentiation, and apoptosis, as well as transformation, invasion and metastasis, depending on cell type and context (7-9). Other target genes regulate survival as well as hypoxia and angiogenesis (8,10). c-Jun has emerged as a promising therapeutic target for cancer, vascular remodeling, acute inflammation, as well as rheumatoid arthritis (11,12). |
| Immunogen | Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S243 of human C-JUN. |
| Other Names | AH119, AP-1, AP1, Activator protein 1, Jun A, Proto-oncogene c-jun, RJG-9, V-jun avian sarcoma virus 17 oncogene homolog, c-Jun, p39, JUN, Transcription factor AP-1, AH119, AH119, AH119, AH119, AP-1, AP-1, AP-1, AP-1, AP1, AP1, AP1, AP1, Activator protein 1, Activator protein 1, Activator protein 1, Activator protein 1, Jun A, Jun A, Jun A, Jun A, Proto-oncogene c-jun, Proto-oncogene c-jun, Proto-oncogene c-jun, Proto-oncogene c-jun, RJG-9, RJG-9, RJG-9, RJG-9, V-jun avian sarcoma virus 17 oncogene homolog, V-jun avian sarcoma virus 17 oncogene homolog, V-jun avian sarcoma virus 17 oncogene homolog, V-jun avian sarcoma virus 17 oncogene homolog, c-Jun, c-Jun, c-Jun, c-Jun, p39, p39, p39, p39, JUN, JUN, JUN, JUN, Transcription factor AP-1, Transcription factor AP-1, Transcription factor AP-1, Transcription factor AP-1 |
| Gene, Accession # | JUN, Gene ID: 3725, UniProt: P05412 |
| Catalog # | abx000135 |
| Price | please inquire |
| Order / More Info | c-Jun (pS243) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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