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Antigenic Specificity | DNA Fragmentation Factor Subunit Alpha (DFFA) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 80 µl, 400 µl, |
Concentration | n/a |
Applications | ELISA, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | DFFA is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. |
Immunogen | KLH-conjugated synthetic peptide between 304-331 amino acids from the C-terminal region of human DFFA. |
Other Names | DFF1, ICAD, DFF-45, DFFA, DFF45, DNA fragmentation factor subunit alpha, DNA fragmentation factor 45 kDa subunit, Inhibitor of CAD, Dna fragmentation factor-45, H13, DFF1, DFF1, DFF1 , DFF1 , ICAD, ICAD, ICAD , ICAD , DFF-45, DFF-45, DFF-45 , DFF-45 , DFFA, DFFA, DFFA , DFFA , DFF45, DFF45, DFF45 , DFF45 , DNA fragmentation factor subunit alpha, DNA fragmentation factor subunit alpha, DNA fragmentation factor subunit alpha , DNA fragmentation factor subunit alpha , DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor 45 kDa subunit , DNA fragmentation factor 45 kDa subunit , Inhibitor of CAD, Inhibitor of CAD, Inhibitor of CAD , Inhibitor of CAD , Dna fragmentation factor-45, Dna fragmentation factor-45, Dna fragmentation factor-45 , Dna fragmentation factor-45 , H13, H13, H13 , H13 |
Gene, Accession # | DFFA, UniProt: O00273 |
Catalog # | abx034309 |
Price | please inquire |
Order / More Info | DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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