Protein Kinase cAMP-Dependent Type II Regulatory Subunit Beta (PRKAR2B) Antibody from ABBEXA LTD

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Antigenic SpecificityProtein Kinase cAMP-Dependent Type II Regulatory Subunit Beta (PRKAR2B)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatpeptide affinity purified
Size80 µl, 400 µl,
Concentrationn/a
ApplicationsELISA, WB
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DescriptioncAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq].
ImmunogenKLH-conjugated synthetic peptide between 119-147 amino acids from the Central region of human PRKAR2B.
Other NamesPRKAR2, RII-BETA, PRKAR2B, cAMP-dependent protein kinase type II-beta regulatory subunit, H_RG363E19.2, protein kinase, cAMP-dependent, regulatory, type II, beta, PKA 2 beta (regulatory subunit), PRKAR2, PRKAR2, PRKAR2 , PRKAR2 , RII-BETA, RII-BETA, RII-BETA , RII-BETA , PRKAR2B, PRKAR2B, PRKAR2B , PRKAR2B , cAMP-dependent protein kinase type II-beta regulatory subunit, cAMP-dependent protein kinase type II-beta regulatory subunit, cAMP-dependent protein kinase type II-beta regulatory subunit , cAMP-dependent protein kinase type II-beta regulatory subunit , H_RG363E19.2, H_RG363E19.2, H_RG363E19.2 , H_RG363E19.2 , protein kinase, protein kinase, protein kinase , protein kinase , cAMP-dependent, cAMP-dependent, cAMP-dependent , cAMP-dependent , regulatory, regulatory, regulatory , regulatory , type II, type II, type II , type II , beta, beta, beta , beta , PKA 2 beta (regulatory subunit), PKA 2 beta (regulatory subunit), PKA 2 beta (regulatory subunit) , PKA 2 beta (regulator
Gene, Accession #PRKAR2B, UniProt: P31323
Catalog #abx028447
Priceplease inquire
Order / More InfoProtein Kinase cAMP-Dependent Type II Regulatory Subunit Beta (PRKAR2B) Antibody from ABBEXA LTD
Product Specific Referencesn/a
ABBEXA LTD
ABBEXA LTD
ABBEXA LTD
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