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Antigenic Specificity | Lymphoid Enhancer Binding Factor 1 (LEF1) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 20 µl, 50 µl, 100 µl, 200 µl |
Concentration | > 0.5 mg/ml |
Applications | WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | LEF1 antibody is a Rabbit polyclonal antibody against LEF1. Lymphoid enhancer-binding factor 1(LEF1) belongs to a family of regulatory protein share homology with high mobility group protein-1, and it's a nuclear protein exprssed in pre-B and T cells. LEF1 has a role in the Wnt signaling pathway and hair cell differentiation and follicle morphogenesis. Together with CTNNB1 and EP300, LEF1 activates transcription of target genes. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. |
Immunogen | Recombinant protein of human LEF1. |
Other Names | KFZp586H0919, TCF1ALPHA, LEF1, LEF-1, TCF7L3, TCF1-alpha, TCF10, lymphoid enhancer-binding factor 1, HGNC:6551, DKFZp586H0919, lymphoid enhancer binding factor-1, T cell-specific transcription factor 1-alpha, Lymphoid Enhancer Binding Factor 1, Lymphoid enhancer-binding factor 1LEF-1, KFZp586H0919, KFZp586H0919, KFZp586H0919 , KFZp586H0919 , TCF1ALPHA, TCF1ALPHA, TCF1ALPHA , TCF1ALPHA , LEF1, LEF1, LEF1 , LEF1 , LEF-1, LEF-1, LEF-1 , LEF-1 , TCF7L3, TCF7L3, TCF7L3 , TCF7L3 , TCF1-alpha, TCF1-alpha, TCF1-alpha , TCF1-alpha , TCF10, TCF10, TCF10 , TCF10 , lymphoid enhancer-binding factor 1, lymphoid enhancer-binding factor 1, lymphoid enhancer-binding factor 1 , lymphoid enhancer-binding factor 1 , HGNC:6551, HGNC:6551, HGNC:6551 , HGNC:6551 , DKFZp586H0919, DKFZp586H0919, DKFZp586H0919 , DKFZp586H0919 , lymphoid enhancer binding factor-1, lymphoid enhancer binding factor-1, lymphoid enhancer binding factor-1 , lymphoid enhancer binding factor-1 , T cell-specific transcription |
Gene, Accession # | LEF1, Gene ID: 51176, UniProt: Q9UJU2 |
Catalog # | abx000894 |
Price | please inquire |
Order / More Info | Lymphoid Enhancer Binding Factor 1 (LEF1) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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