E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-E3 Ubiquitin-Protein Ligase CBL-B (CBLB) antibody, protein, ELISA kits.
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| Antigenic Specificity | E3 Ubiquitin-Protein Ligase CBL-B (CBLB) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, FCM |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. It also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. It may also be involved in EGFR ubiquitination and internalization. |
| Immunogen | KLH-conjugated synthetic peptide between 103-130 amino acids from the Central region of human CBLB. |
| Other Names | Cas-Br-M (murine) ecotropic retroviral transforming sequence b, CBLB, DKFZp686J10223, DKFZp779A0729, DKFZp779F1443, FLJ36865, FLJ41152, Nbla00127, RNF56, E3 ubiquitin-protein ligase CBL-B, Casitas B-lineage lymphoma proto-oncogene b, RING finger protein 56, SH3-binding protein CBL-B, Signal transduction protein CBL-B, Cbl-b, Cas-Br-M (murine) ecotropic retroviral transforming sequence b, Cas-Br-M (murine) ecotropic retroviral transforming sequence b, Cas-Br-M (murine) ecotropic retroviral transforming sequence b , Cas-Br-M (murine) ecotropic retroviral transforming sequence b , CBLB, CBLB, CBLB , CBLB , DKFZp686J10223, DKFZp686J10223, DKFZp686J10223 , DKFZp686J10223 , DKFZp779A0729, DKFZp779A0729, DKFZp779A0729 , DKFZp779A0729 , DKFZp779F1443, DKFZp779F1443, DKFZp779F1443 , DKFZp779F1443 , FLJ36865, FLJ36865, FLJ36865 , FLJ36865 , FLJ41152, FLJ41152, FLJ41152 , FLJ41152 , Nbla00127, Nbla00127, Nbla00127 , Nbla00127 , RNF56, RNF56, RNF56 , RNF56 , E3 ubiquitin-protein ligase CB |
| Gene, Accession # | CBLB, Gene ID: 868, UniProt: Q13191 |
| Catalog # | abx034055 |
| Price | please inquire |
| Order / More Info | E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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