FAS (pY291) Antibody from ABBEXA LTD
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| Antigenic Specificity | FAS (pY291) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | FAS (pY291) Antibody is a Rabbit Polyclonal antibody against FAS (pY291). Association of the receptor Fas with its ligand FasL triggers an apoptotic pathway that plays an important role in immune regulation, development, and progression of cancers (1,2). Loss of function mutation in either Fas (lpr mice) or FasL (gld mice) leads to lymphadenopathy and splenomegaly as a result of decreased apoptosis in CD4-CD8- T lymphocytes (3,4). FasL (CD95L, Apo-1L) is a type II transmembrane protein of 280 amino acids (runs at approximately 40 kDa upon glycosylation) that belongs to the TNF family, which also includes TNF-α, TRAIL, and TWEAK. Binding of FasL to its receptor triggers the formation of a death-inducing signaling complex (DISC) involving the recruitment of the adaptor protein FADD and caspase-8 (5). Activation of caspase-8 from this complex initiates a caspase cascade resulting in the activation of caspase-3 and subsequent cleavage of proteins leading to apoptosis. Unlike Fas, which is constitutively expressed by various cell types, FasL is predominantly expressed on activated T lymphocytes, NK cells, and at immune privileged sites (6). FasL is also expressed in several tumor types as a mechanism to evade immune surveillance (7). Similar to other members of the TNF family, FasL can be cleaved by metalloproteinases producing a 26 kDa trimeric soluble form (8,9). |
| Immunogen | Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y291 of human FAS. |
| Other Names | Apo-1 Antigen, Apoptosis-Mediating Surface Antigen Fas, Faslg Receptor, Cd95, Apoptosis-mediating surface antigen, FAS, Apo-1, FasL receptor, TNFRSF6, TNR6, tumor necrosis factor receptor superfamily member 6, APT1, FAS1, FASTM, ALPS1A, Fas (TNF receptor superfamily, member 6), APO-1 cell surface antigen, CD95 antigen, Fas AMA, Fas antigen, OTTHUMP00000020045, OTTHUMP00000020046, OTTHUMP00000020051, OTTHUMP00000059646, apoptosis antig, Apo-1 Antigen, Apo-1 Antigen, Apo-1 Antigen, Apo-1 Antigen, Apoptosis-Mediating Surface Antigen Fas, Apoptosis-Mediating Surface Antigen Fas, Apoptosis-Mediating Surface Antigen Fas, Apoptosis-Mediating Surface Antigen Fas, Faslg Receptor, Faslg Receptor, Faslg Receptor, Faslg Receptor, Cd95, Cd95, Cd95, Cd95, Apoptosis-mediating surface antigen, Apoptosis-mediating surface antigen, Apoptosis-mediating surface antigen, Apoptosis-mediating surface antigen, FAS, FAS, FAS, FAS, Apo-1, Apo-1, Apo-1, Apo-1, FasL receptor, FasL receptor, FasL receptor, FasL receptor, TNFRSF6, TNFRSF6, TNFRSF6, TNFRSF6, TNR6, TNR6, TNR6, TNR6, tumor necrosis factor receptor superfamily member 6, tumor necrosis factor receptor superfamily member 6, tumor necrosis factor receptor superfamily member 6, tumor necrosis factor receptor superfamily member 6, APT1, APT1, APT1, APT1, FAS1, FAS1, FAS1, FAS1, FASTM, FASTM, FASTM, FASTM, ALPS1A, ALPS1A, ALPS1A, ALPS1A, Fas (TNF receptor superfamily, member 6), Fas (TNF receptor superfamily, member 6), Fas (TNF receptor superfamily, member 6), Fas (TNF receptor superfamily, member 6), APO-1 cell surface antigen, APO-1 cell surface antigen, APO-1 cell surface antigen, APO-1 cell surface antigen, CD95 antigen, CD95 antigen, CD95 antigen, CD95 antigen, Fas AMA, Fas AMA, Fas AMA, Fas AMA, Fas antigen, Fas antigen, Fas antigen, Fas antigen, OTTHUMP00000020045, OTTHUMP00000020045, OTTHUMP00000020045, OTTHUMP00000020045, OTTHUMP00000020046, OTTHUMP00000020046, OTTHUMP00000020046, OTTHUMP00000020046, OTTHUMP00000020051, OTTHUMP00000020051, OTTHUMP00000020051, OTTHUMP00000020051, OTTHUMP00000059646, OTTHUMP00000059646, OTTHUMP00000059646, OTTHUMP00000059646, apoptosis antig, apoptosis antig, apoptosis antig, apoptosis antig |
| Gene, Accession # | FAS, Gene ID: 355, UniProt: P25445 |
| Catalog # | abx000097 |
| Price | please inquire |
| Order / More Info | FAS (pY291) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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