Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. |
| Immunogen | KLH-conjugated synthetic peptide between 183-212 amino acids from the Central region of human PPM1D. |
| Other Names | PPM1D, WIP1, Protein phosphatase 1D, Protein phosphatase 2C isoform delta, Protein phosphatase magnesium-dependent 1 delta, p53-induced protein phosphatase 1, PP2C-delta, PPM1D, PPM1D, PPM1D , PPM1D , WIP1, WIP1, WIP1 , WIP1 , Protein phosphatase 1D, Protein phosphatase 1D, Protein phosphatase 1D , Protein phosphatase 1D , Protein phosphatase 2C isoform delta, Protein phosphatase 2C isoform delta, Protein phosphatase 2C isoform delta , Protein phosphatase 2C isoform delta , Protein phosphatase magnesium-dependent 1 delta, Protein phosphatase magnesium-dependent 1 delta, Protein phosphatase magnesium-dependent 1 delta , Protein phosphatase magnesium-dependent 1 delta , p53-induced protein phosphatase 1, p53-induced protein phosphatase 1, p53-induced protein phosphatase 1 , p53-induced protein phosphatase 1 , PP2C-delta, PP2C-delta, PP2C-delta , PP2C-delta |
| Gene, Accession # | PPM1D, UniProt: O15297 |
| Catalog # | abx027662 |
| Price | please inquire |
| Order / More Info | Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies