P21CIP1 (pT145) Antibody from ABBEXA LTD
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| Antigenic Specificity | P21CIP1 (pT145) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC, DB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | P21CIP1 is a potent cyclin-dependent kinase inhibitor. This protein binds to and inhibits the activity of cyclin-CDK2 or CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. Expression is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. P21CIP1 can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein has been reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T145 of human P21CIP1. |
| Other Names | CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, p21, DNA synthesis inhibitor, p21CIP1, CDK-interaction protein 1, MDA-6, CDKN1A, CDKN1A, CDKN1A , CDKN1A , CAP20, CAP20, CAP20 , CAP20 , CDKN1, CDKN1, CDKN1 , CDKN1 , CIP1, CIP1, CIP1 , CIP1 , MDA6, MDA6, MDA6 , MDA6 , PIC1, PIC1, PIC1 , PIC1 , SDI1, SDI1, SDI1 , SDI1 , WAF1, WAF1, WAF1 , WAF1 , Cyclin-dependent kinase inhibitor 1, Cyclin-dependent kinase inhibitor 1, Cyclin-dependent kinase inhibitor 1 , Cyclin-dependent kinase inhibitor 1 , CDK-interacting protein 1, CDK-interacting protein 1, CDK-interacting protein 1 , CDK-interacting protein 1 , Melanoma differentiation-associated protein 6, Melanoma differentiation-associated protein 6, Melanoma differentiation-associated protein 6 , Melanoma differentiation-associated protein 6 , p21, p21, p21 , p21 , DNA synthesis inhibitor, DNA synthesis inhibitor, DNA s |
| Gene, Accession # | NCBI: NP_000380.1, NP_001207706.1, NP_001207707.1, NP_510867.1, UniProt: P38936 |
| Catalog # | abx031888 |
| Price | please inquire |
| Order / More Info | P21CIP1 (pT145) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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