E3 Ubiquitin-Protein Ligase RFWD2 (RFWD2) Antibody from ABBEXA LTD
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| Antigenic Specificity | E3 Ubiquitin-Protein Ligase RFWD2 (RFWD2) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. |
| Immunogen | KLH-conjugated synthetic peptide between 672-701 amino acids from the C-terminal region of human RFWD2. |
| Other Names | Constitutive photomorphogenesis protein 1 homolog, COP1, hCOP1, RING finger and WD repeat domain protein 2, Ubiquitin- protein ligase COP1, RFWD2 (Ab-387), RFWD2, RNF200, E3 ubiquitin-protein ligase RFWD2, RING finger protein 200, Constitutive photomorphogenesis protein 1 homolog, Constitutive photomorphogenesis protein 1 homolog, Constitutive photomorphogenesis protein 1 homolog , Constitutive photomorphogenesis protein 1 homolog , COP1, COP1, COP1 , COP1 , hCOP1, hCOP1, hCOP1 , hCOP1 , RING finger and WD repeat domain protein 2, RING finger and WD repeat domain protein 2, RING finger and WD repeat domain protein 2 , RING finger and WD repeat domain protein 2 , Ubiquitin- protein ligase COP1, Ubiquitin- protein ligase COP1, Ubiquitin- protein ligase COP1 , Ubiquitin- protein ligase COP1 , RFWD2 (Ab-387), RFWD2 (Ab-387), RFWD2 (Ab-387) , RFWD2 (Ab-387) , RFWD2, RFWD2, RFWD2 , RFWD2 , RNF200, RNF200, RNF200 , RNF200 , E3 ubiquitin-protein ligase RFWD2, E3 ubiquitin-protein liga |
| Gene, Accession # | COP1, UniProt: Q8NHY2 |
| Catalog # | abx031297 |
| Price | please inquire |
| Order / More Info | E3 Ubiquitin-Protein Ligase RFWD2 (RFWD2) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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