Mouse Stk4 Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Mouse Stk4 antibody, protein, ELISA kits.
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| Antigenic Specificity | Mouse Stk4 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. |
| Immunogen | KLH-conjugated synthetic peptide between 443-470 amino acids from the C-terminal region of mouse Stk4. |
| Other Names | Stk4, Mst1, Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1, STE20-like kinase MST1, Serine/threonine-protein kinase 4 37kDa subunit, Serine/threonine-protein kinase 4 18kDa subunit, Stk4, Stk4, Stk4 , Stk4 , Mst1, Mst1, Mst1 , Mst1 , Serine/threonine-protein kinase 4, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase 4 , Serine/threonine-protein kinase 4 , Mammalian STE20-like protein kinase 1, Mammalian STE20-like protein kinase 1, Mammalian STE20-like protein kinase 1 , Mammalian STE20-like protein kinase 1 , STE20-like kinase MST1, STE20-like kinase MST1, STE20-like kinase MST1 , STE20-like kinase MST1 , Serine/threonine-protein kinase 4 37kDa subunit, Serine/threonine-protein kinase 4 37kDa subunit, Serine/threonine-protein kinase 4 37kDa subunit , Serine/threonine-protein kinase 4 37kDa subunit , Serine/threonine-protein kinase 4 18kDa subunit, Serine/threonine-protein kinase 4 18kDa subunit, Serine/threonine-protein kinase 4 18kDa |
| Gene, Accession # | UniProt: Q9JI11 |
| Catalog # | abx029444 |
| Price | please inquire |
| Order / More Info | Mouse Stk4 Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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