Tumor Necrosis Factor Alpha-Induced Protein 3 (TNFAIP3) Antibody from ABBEXA LTD
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| Antigenic Specificity | Tumor Necrosis Factor Alpha-Induced Protein 3 (TNFAIP3) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Tumor Necrosis Factor Alpha-Induced Protein 3 (TNFAIP3) antibody is a Rabbit polyclonal antibody for the detection of TNFAIP3. Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF-or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR) -mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'-and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages. |
| Immunogen | tumor necrosis factor, alpha-induced protein 3 |
| Other Names | A20, OTUD7C, TNF alpha induced protein 3, TNFA1P2, TNFAIP3, Zinc finger protein A20, A20, A20, A20 , A20 , OTUD7C, OTUD7C, OTUD7C , OTUD7C , TNF alpha induced protein 3, TNF alpha induced protein 3, TNF alpha induced protein 3 , TNF alpha induced protein 3 , TNFA1P2, TNFA1P2, TNFA1P2 , TNFA1P2 , TNFAIP3, TNFAIP3, TNFAIP3 , TNFAIP3 , Zinc finger protein A20, Zinc finger protein A20, Zinc finger protein A20 , Zinc finger protein A20 |
| Gene, Accession # | TNFAIP3, Gene ID: 7128, UniProt: P21580 |
| Catalog # | abx147829 |
| Price | please inquire |
| Order / More Info | Tumor Necrosis Factor Alpha-Induced Protein 3 (TNFAIP3) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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