Nibrin (NBN) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Nibrin (NBN) antibody, protein, ELISA kits.
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| Antigenic Specificity | Nibrin (NBN) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 20 µl, 50 µl, 100 µl, 200 µl |
| Concentration | > 0.5 mg/ml |
| Applications | WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | NBN antibody is a Rabbit polyclonal antibody against NBN. NBN, also named as NBS, NBS1 and P95, is a component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. Defects in NBN are the cause of Nijmegen breakage syndrome (NBS). Defects in NBN are a cause of genetic susceptibility to breast cancer (BC). Defects in NBN may be associated with aplastic anemia. Defects in NBN might play a role in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). The antibody is specific to NBN. |
| Immunogen | A synthetic peptide of human NBN. |
| Other Names | ATV, NBS, P95, NBS1, AT-V1, AT-V2, FLJ10155, MGC87362, NBN, Nibrin, Cell cycle regulatory protein p95, Nijmegen breakage syndrome protein 1, ATV, ATV, ATV , ATV , NBS, NBS, NBS , NBS , P95, P95, P95 , P95 , NBS1, NBS1, NBS1 , NBS1 , AT-V1, AT-V1, AT-V1 , AT-V1 , AT-V2, AT-V2, AT-V2 , AT-V2 , FLJ10155, FLJ10155, FLJ10155 , FLJ10155 , MGC87362, MGC87362, MGC87362 , MGC87362 , NBN, NBN, NBN , NBN , Nibrin, Nibrin, Nibrin , Nibrin , Cell cycle regulatory protein p95, Cell cycle regulatory protein p95, Cell cycle regulatory protein p95 , Cell cycle regulatory protein p95 , Nijmegen breakage syndrome protein 1, Nijmegen breakage syndrome protein 1, Nijmegen breakage syndrome protein 1 , Nijmegen breakage syndrome protein 1 |
| Gene, Accession # | NBN, Gene ID: 4683, UniProt: O60934 |
| Catalog # | abx000860 |
| Price | please inquire |
| Order / More Info | Nibrin (NBN) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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