Proto-Oncogene C-Cot (COT) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Proto-Oncogene C-Cot (COT) antibody, protein, ELISA kits.
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| Antigenic Specificity | Proto-Oncogene C-Cot (COT) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK8 is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. The protein appears to play an important role in the cell cycle. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues. |
| Immunogen | KLH-conjugated synthetic peptide between 414-445 amino acids from the C-terminal region of human COT (MAP3K8/MEKK8). |
| Other Names | COT proto-oncogene serine/threonine-protein kinase, c-COT, Cancer Osaka thyroid oncogene, Tumor progression locus 2, TPL-2, MAP3K8, COT, ESTF, Mitogen-activated protein kinase kinase kinase 8, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, COT proto-oncogene serine/threonine-protein kinase, COT proto-oncogene serine/threonine-protein kinase, COT proto-oncogene serine/threonine-protein kinase , COT proto-oncogene serine/threonine-protein kinase , c-COT, c-COT, c-COT , c-COT , Cancer Osaka thyroid oncogene, Cancer Osaka thyroid oncogene, Cancer Osaka thyroid oncogene , Cancer Osaka thyroid oncogene , Tumor progression locus 2, Tumor progression locus 2, Tumor progression locus 2 , Tumor progression locus 2 , TPL-2, TPL-2, TPL-2 , TPL-2 , MAP3K8, MAP3K8, MAP3K8 , MAP3K8 , COT, COT, COT , COT , ESTF, ESTF, ESTF , ESTF , Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase 8 , |
| Gene, Accession # | UniProt: P41279 |
| Catalog # | abx033760 |
| Price | please inquire |
| Order / More Info | Proto-Oncogene C-Cot (COT) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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