DNA Methyltransferase 1 (Dnmt1) Antibody from ABBEXA LTD

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Antigenic SpecificityDNA Methyltransferase 1 (Dnmt1)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatimmunogen affinity purified
Size100 µg,
Concentration2 mg/ml
ApplicationsELISA, IHC
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DescriptionDNA Methyltransferase 1 (Dnmt1) antibody is a Rabbit polyclonal antibody for the detection of DNMT1.

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306).
ImmunogenDNA(cytosine-5-)-methyltransferase 1
Other NamesDNA Methyltransferase 1, DNMT1, DNA Methyltransferase 1, DNA Methyltransferase 1, DNA Methyltransferase 1 , DNA Methyltransferase 1 , DNMT1, DNMT1, DNMT1 , DNMT1
Gene, Accession #DNMT1, Gene ID: 1786, UniProt: P26358
Catalog #abx148089
Priceplease inquire
Order / More InfoDNA Methyltransferase 1 (Dnmt1) Antibody from ABBEXA LTD
Product Specific Referencesn/a
ABBEXA LTD
ABBEXA LTD
ABBEXA LTD
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