Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM 17) Antibody from ABBEXA LTD
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| Antigenic Specificity | Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM 17) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 100 µg, |
| Concentration | 2 mg/ml |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM 17) antibody is a Rabbit polyclonal antibody for the detection of ADAM17. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. |
| Immunogen | ADAM metallopeptidase domain 17 |
| Other Names | ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme, ADAM 17, ADAM 17, ADAM 17 , ADAM 17 , ADAM17, ADAM17, ADAM17 , ADAM17 , CD156b, CD156b, CD156b , CD156b , cSVP, cSVP, cSVP , cSVP , Snake venom like protease, Snake venom like protease, Snake venom like protease , Snake venom like protease , TACE, TACE, TACE , TACE , TNF alpha convertase, TNF alpha convertase, TNF alpha convertase , TNF alpha convertase , TNF alpha converting enzyme, TNF alpha converting enzyme, TNF alpha converting enzyme , TNF alpha converting enzyme |
| Gene, Accession # | ADAM17, Gene ID: 6868, UniProt: P78536 |
| Catalog # | abx020064 |
| Price | please inquire |
| Order / More Info | Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM 17) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
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