ErbB2 (pY1222) Antibody from ABBEXA LTD
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| Antigenic Specificity | ErbB2 (pY1222) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl, |
| Concentration | n/a |
| Applications | ELISA, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1222 of human ERBB2. |
| Other Names | ERBB2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, c-erb B2/neu protein, herstatin, metastatic lymph node gene 19 protein, neuroblas, ERBB2, ERBB2, ERBB2 , ERBB2 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) , v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) , CD340, CD340, CD340 , CD340 , HER-2, HER-2, HER-2 , HER-2 , HER-2/neu, HER-2/neu, HER-2/neu , HER-2/neu , HER2, HER2, HER2 , HER2 , MLN 19, MLN 19, MLN 19 , MLN 19 , NEU, NEU, NEU , NEU , NGL, NGL, NGL , NGL , TKR1, TKR1, TKR1 , TKR1 , c-erb B2/neu prot |
| Gene, Accession # | NCBI: NP_001005862.1, NP_004439.2, UniProt: P04626 |
| Catalog # | abx035003 |
| Price | please inquire |
| Order / More Info | ErbB2 (pY1222) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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