Edit |   |
---|---|
Antigenic Specificity | Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | ascites |
Size | 100 µl, |
Concentration | n/a |
Applications | ELISA, WB, IF/ICC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases. |
Immunogen | Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells. |
Other Names | Neurotrophic Tyrosine Kinase, Receptor-Related 1 Ror1 Ntrkr1, NTRKR1, dJ537F10.1, ROR1, Tyrosine-protein kinase transmembrane receptor ROR1, receptor-related 1, receptor tyrosine kinase-like orphan receptor 1, MGC99659, neurotrophic tyrosine kinase receptor-related 1, Neurotrophic Tyrosine Kinase, Neurotrophic Tyrosine Kinase, Neurotrophic Tyrosine Kinase , Neurotrophic Tyrosine Kinase , Receptor-Related 1 Ror1 Ntrkr1, Receptor-Related 1 Ror1 Ntrkr1, Receptor-Related 1 Ror1 Ntrkr1 , Receptor-Related 1 Ror1 Ntrkr1 , NTRKR1, NTRKR1, NTRKR1 , NTRKR1 , dJ537F10.1, dJ537F10.1, dJ537F10.1 , dJ537F10.1 , ROR1, ROR1, ROR1 , ROR1 , Tyrosine-protein kinase transmembrane receptor ROR1, Tyrosine-protein kinase transmembrane receptor ROR1, Tyrosine-protein kinase transmembrane receptor ROR1 , Tyrosine-protein kinase transmembrane receptor ROR1 , receptor-related 1, receptor-related 1, receptor-related 1 , receptor-related 1 , receptor tyrosine kinase-like orphan receptor 1, receptor tyrosin |
Gene, Accession # | ROR1, Gene ID: 4919, UniProt: Q01973 |
Catalog # | abx011486 |
Price | please inquire |
Order / More Info | Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) Antibody from ABBEXA LTD |
Product Specific References | n/a |
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950