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Antigenic Specificity | Mothers Against Decapentaplegic Homolog 4 (SMAD4) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 20 µl, 50 µl, 100 µl, 200 µl |
Concentration | > 0.5 mg/ml |
Applications | WB, IHC, IF/ICC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | SMAD4 antibody is a Rabbit polyclonal antibody against SMAD4. This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. |
Immunogen | Recombinant protein of human SMAD4. |
Other Names | deleted in pancreatic carcinoma locus 4, Deletion target in pancreatic carcinoma 4, DPC4, hSMAD4, JIP, MAD homolog 4, MAD, mothers against decapentaplegic homolog 4, MADH4, mothers against decapentaplegic, Drosophila, homolog of, 4, Mothers against DPP homolog 4, SMAD 4, SMAD family member 4, SMAD, SMAD4, MYHRS, deleted in pancreatic carcinoma locus 4, deleted in pancreatic carcinoma locus 4, deleted in pancreatic carcinoma locus 4 , deleted in pancreatic carcinoma locus 4 , Deletion target in pancreatic carcinoma 4, Deletion target in pancreatic carcinoma 4, Deletion target in pancreatic carcinoma 4 , Deletion target in pancreatic carcinoma 4 , DPC4, DPC4, DPC4 , DPC4 , hSMAD4, hSMAD4, hSMAD4 , hSMAD4 , JIP, JIP, JIP , JIP , MAD homolog 4, MAD homolog 4, MAD homolog 4 , MAD homolog 4 , MAD, MAD, MAD , MAD , mothers against decapentaplegic homolog 4, mothers against decapentaplegic homolog 4, mothers against decapentaplegic homolog 4 , mothers against decapentaplegic homolog 4 |
Gene, Accession # | SMAD4, Gene ID: 4089, UniProt: Q13485 |
Catalog # | abx004327 |
Price | please inquire |
Order / More Info | Mothers Against Decapentaplegic Homolog 4 (SMAD4) Antibody from ABBEXA LTD |
Product Specific References | n/a |
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