Cellular Apoptosis Susceptibility Antibody from ABBEXA LTD

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Antigenic SpecificityCellular Apoptosis Susceptibility
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse
Isotypen/a
FormatProtein G purified
Size80 µl, 400 µl,
Concentrationn/a
ApplicationsELISA, WB, IHC, IF/ICC
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DescriptionProteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, CSE1L may play a role both in apoptosis and in cell proliferation.
ImmunogenKLH-conjugated synthetic peptide between 55-84 amino acids from the C-terminal region of human Cellular Apoptosis Susceptibility.
Other NamesCSE1L, CAS, XPO2, Exportin-2, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Importin-alpha re-exporter, CSE1L, CSE1L, CSE1L , CSE1L , CAS, CAS, CAS , CAS , XPO2, XPO2, XPO2 , XPO2 , Exportin-2, Exportin-2, Exportin-2 , Exportin-2 , Cellular apoptosis susceptibility protein, Cellular apoptosis susceptibility protein, Cellular apoptosis susceptibility protein , Cellular apoptosis susceptibility protein , Chromosome segregation 1-like protein, Chromosome segregation 1-like protein, Chromosome segregation 1-like protein , Chromosome segregation 1-like protein , Importin-alpha re-exporter, Importin-alpha re-exporter, Importin-alpha re-exporter , Importin-alpha re-exporter
Gene, Accession #NCBI: NP_001243064.1, NP_001307.2, UniProt: P55060
Catalog #abx030969
Priceplease inquire
Order / More InfoCellular Apoptosis Susceptibility Antibody from ABBEXA LTD
Product Specific Referencesn/a
ABBEXA LTD
ABBEXA LTD
ABBEXA LTD
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Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950

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